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Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

ABSTRACT: A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered different alkyl chain lengths and triazole positions. The compounds were subsequently tested against Mycobacterium tuberculosis, being most of them active with some of the analogs displaying activity at micromolar concentration. The most potent member of the series has the triazole moiety on the C-2 position with a carbon chain of eight or ten carbon atoms. The 1,5-isomers of the most active analog were significantly less active than the original isomer. The activity of the selected hit was assayed on several clinical MTB multi-drug resistant strains providing the same MIC.

SUBMITTER: Ghiano DG

PROVIDER: S-EPMC5148633 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

Ghiano Diego G DG de la Iglesia Agustina A Liu Nina N Tonge Peter J PJ Morbidoni Héctor R HR Labadie Guillermo R GR

European journal of medicinal chemistry 20160928

A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered different alkyl chain lengths and triazole positions. The compounds were subsequently tested against Mycobacterium tuberculosis, being most of them active with some of the analogs displaying activity at micromolar concentration. The most potent member of the series has the triazole moiety on the C-2 position with a carbon chain of eight or ...[more]

PMID: 27750201

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