A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.
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ABSTRACT:
SUBMITTER: Rucker E
PROVIDER: S-EPMC514962 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
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A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.
Rücker Elke E Münch Jan J Wildum Steffen S Brenner Matthias M Eisemann Jutta J Margolis Leonid L Kirchhoff Frank F
Journal of virology 20040901 18
We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-rich region does not significantly affect the functional activity of Nef or HIV-1 infectivity or replication. ...[more]
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