Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.
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ABSTRACT:
SUBMITTER: Chmiest D
PROVIDER: S-EPMC5150223 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.
Chmiest Daniela D Sharma Nanaocha N Zanin Natacha N Viaris de Lesegno Christine C Shafaq-Zadah Massiullah M Sibut Vonick V Dingli Florent F Hupé Philippe P Wilmes Stephan S Piehler Jacob J Loew Damarys D Johannes Ludger L Schreiber Gideon G Lamaze Christophe C
Nature communications 20161205
Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by the retromer at the early endosome. Binding of the retromer VPS35 subunit to IFNAR2 results in IFNAR2 re ...[more]
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