Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava A
PROVIDER: S-EPMC5150529 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Srivastava Akhil A Amreddy Narsireddy N Babu Anish A Panneerselvam Janani J Mehta Meghna M Muralidharan Ranganayaki R Chen Allshine A Zhao Yan Daniel YD Razaq Mohammad M Riedinger Natascha N Kim Hogyoung H Liu Shaorong S Wu Si S Abdel-Mageed Asim B AB Munshi Anupama A Ramesh Rajagopal R
Scientific reports 20161212
Successful chemotherapeutic intervention for management of lung cancer requires an efficient drug delivery system. Gold nanoparticles (GNPs) can incorporate various therapeutics; however, GNPs have limitations as drug carriers. Nano-sized cellular vesicles like exosomes (Exo) can ferry GNP-therapeutic complexes without causing any particle aggregation or immune response. In the present study, we describe the development and testing of a novel Exo-GNP-based therapeutic delivery system -'nanosomes ...[more]