Ontology highlight
ABSTRACT:
SUBMITTER: Pronker MF
PROVIDER: S-EPMC5150538 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pronker Matti F MF Lemstra Suzanne S Snijder Joost J Heck Albert J R AJ Thies-Weesie Dominique M E DM Pasterkamp R Jeroen RJ Janssen Bert J C BJ
Nature communications 20161206
Myelin-associated glycoprotein (MAG) is a myelin-expressed cell-adhesion and bi-directional signalling molecule. MAG maintains the myelin-axon spacing by interacting with specific neuronal glycolipids (gangliosides), inhibits axon regeneration and controls myelin formation. The mechanisms underlying MAG adhesion and signalling are unresolved. We present crystal structures of the MAG full ectodomain, which reveal an extended conformation of five Ig domains and a homodimeric arrangement involving ...[more]