Unknown

Dataset Information

0

A nomogram improves AJCC stages for colorectal cancers by introducing CEA, modified lymph node ratio and negative lymph node count.


ABSTRACT: Lymph node stages (pN stages) are primary contributors to survival heterogeneity of the 7th AJCC staging system for colorectal cancer (CRC), indicating spaces for modifications. To implement the modifications, we selected eligible CRC patients from the Surveillance Epidemiology and End Results (SEER) database as participants in a training (n?=?6675) and a test cohort (n?=?6760), and verified tumor deposits to be metastatic lymph nodes to derive modified lymph node count (mLNC), lymph node ratio (mLNR), and positive lymph node count (mPLNC). After multivariate Cox regression analyses with forward stepwise elimination of the mLNC and mPLNC for the training cohort, a nomogram was constructed to predict overall survival (OS) via incorporating preoperative carcinoembryonic antigen, pT stages, negative lymph node count, mLNR and metastasis. Internal validations of the nomogram showed concordance indexes (c-index) of 0.750 (95% CI, 0.736-0.764) and 0.749 before and after corrections for overfitting. Serial performance evaluations indicated that the nomogram outperformed the AJCC stages (c-index?=?0.725) with increased accuracy, net benefits, risk assessment ability, but comparable complexity and clinical validity. All the results were reproducible in the test cohort. In summary, the proposed nomogram may serve as an alternative to the AJCC stages. However, validations with longer follow-up periods are required.

SUBMITTER: Zhang ZY 

PROVIDER: S-EPMC5150581 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

A nomogram improves AJCC stages for colorectal cancers by introducing CEA, modified lymph node ratio and negative lymph node count.

Zhang Zhen-Yu ZY   Gao Wei W   Luo Qi-Feng QF   Yin Xiao-Wei XW   Basnet Shiva S   Dai Zhen-Ling ZL   Ge Hai-Yan HY  

Scientific reports 20161212


Lymph node stages (pN stages) are primary contributors to survival heterogeneity of the 7<sup>th</sup> AJCC staging system for colorectal cancer (CRC), indicating spaces for modifications. To implement the modifications, we selected eligible CRC patients from the Surveillance Epidemiology and End Results (SEER) database as participants in a training (n = 6675) and a test cohort (n = 6760), and verified tumor deposits to be metastatic lymph nodes to derive modified lymph node count (mLNC), lymph  ...[more]

Similar Datasets

| S-EPMC8099056 | biostudies-literature
| S-EPMC5804271 | biostudies-literature
2013-10-26 | GSE51725 | GEO
2013-10-26 | E-GEOD-51725 | biostudies-arrayexpress
| S-EPMC6843880 | biostudies-literature
| S-EPMC5858777 | biostudies-literature
| S-EPMC8144194 | biostudies-literature
| S-EPMC7747752 | biostudies-literature
| S-EPMC8107679 | biostudies-literature
| S-EPMC4722923 | biostudies-literature