Ontology highlight
ABSTRACT:
SUBMITTER: Katsushima K
PROVIDER: S-EPMC5150648 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nature communications 20161206
Targeting self-renewal is an important goal in cancer therapy and recent studies have focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs). Understanding cancer-specific Notch regulation would improve specificity of targeting this pathway. In this study, we find that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1. TUG1 coordinately promotes self-renewal by sponging miR-145 in the cytoplasm and recruiting polycomb to repress differe ...[more]