Ontology highlight
ABSTRACT:
SUBMITTER: Velazquez F
PROVIDER: S-EPMC5150670 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Velázquez Francisco F Chelliah Mariappan M Clasby Martin M Guo Zhuyan Z Howe John J Miller Randy R Neelamkavil Santhosh S Shah Unmesh U Soriano Aileen A Xia Yan Y Venkatraman Srikanth S Chackalamannil Samuel S Davies Ian W IW
ACS medicinal chemistry letters 20161017 12
A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic proline-P2 surrogate onto the P2-P4 macrocyclic core of MK-5172 (grazoprevir). The potency profile of new analogues showed excellent pan-genotypic activity for most compounds. The potency evaluation included the most difficult genotype 3a (EC<sub>50</sub> values ≤10 nM) and other key genotype 1b mutants. Molecular modeling was used to design new target compounds and rationalize our results. A synthetic ...[more]