Ontology highlight
ABSTRACT:
SUBMITTER: Shnyreva M
PROVIDER: S-EPMC515107 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Shnyreva Maria M Weaver William M WM Blanchette Mathieu M Taylor Scott L SL Tompa Martin M Fitzpatrick David R DR Wilson Christopher B CB
Proceedings of the National Academy of Sciences of the United States of America 20040810 34
Our understanding of mechanisms by which the expression of IFN-gamma is regulated is limited. Herein, we identify two evolutionarily conserved noncoding sequence elements (IFNgCNS1 and IFNg CNS2) located approximately 5 kb upstream and approximately 18 kb downstream of the initiation codon of the murine Ifng gene. When linked to the murine Ifng gene (-3.4 to +5.6 kb) and transiently transfected into EL-4 cells, these elements clearly enhanced IFN-gamma expression in response to ionomycin and pho ...[more]