Ontology highlight
ABSTRACT:
SUBMITTER: Yamada A
PROVIDER: S-EPMC5151144 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160915 12
We report here development of <i>N</i>-(4-phenoxyphenyl)benzenesulfonamide derivatives as a novel class of nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiological systems, including the female reproductive system, and PR antagonists are candidates for clinical treatment of multiple diseases, including uterine leiomyoma, endometriosis, breast cancer, and some psychiatric disorders. We found that the benzenesulfonanilide skeleton functions as a novel scaffo ...[more]