Ontology highlight
ABSTRACT:
SUBMITTER: Thiviyanathan V
PROVIDER: S-EPMC515117 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Thiviyanathan Varatharasa V Yang Yan Y Kaluarachchi Kumaralal K Rijnbrand Rene R Gorenstein David G DG Lemon Stanley M SM
Proceedings of the National Academy of Sciences of the United States of America 20040816 34
Picornaviruses constitute a medically important family of RNA viruses in which genome replication critically depends on a small RNA element, the cis-acting replication element (cre), that templates 3D(pol) polymerase-catalyzed uridylylation of the protein primer for RNA synthesis, VPg. We report the solution structure of the 33-nt cre of human rhinovirus 14 under solution conditions optimal for uridylylation in vitro. The cre adopts a stem-loop conformation with an extended duplex stem supportin ...[more]