Dataset Information

Adiposity during adolescence and carotid intima-media thickness in adulthood: Results from the 1993 Pelotas Birth Cohort.

ABSTRACT:

Background and aims

Although several studies have examined the association between adiposity and cardiovascular risk markers, few have explored the issue prospectively in young populations. We sought to test whether higher levels of body mass index (BMI) and subscapular skinfold at different stages of adolescence were associated with carotid intima-media thickness (cIMT) in young adulthood.

Methods

In a prospective cohort, we assessed BMI and subscapular skinfold at 11, 15 and 18 years and measured cIMT at 18 years in 3264 individuals. Traditional cardiovascular risk factors and fat mass-mediating effects on cIMT were also assessed.

Results

Both BMI and subscapular skinfolds were significantly associated with higher cIMT in a cummulative fashion: after controlling for confounders, males and females who persisted overweight/obese at all three assessments, had a mean higher cIMT (5.2 and 3.1 ?m, respectively) compared to males and females with normal/healthy BMI at each evaluation (p < 0.001). Moreover, male and females that presented increased fatness in all assessments had a similar pattern of higher cIMT compared to normal/healthy fatness/skinfold at 18 years (mean cIMT 4.6 and 3.0 ?m for males and females, respectively; p < 0.001). Associations between adiposity and cIMT were both direct and indirect. Indirect effects were chiefly mediated by fat mass and diastolic blood pressure.

Conclusions

Our results suggest adiposity exerts direct and indirect effects during adolescence that result in higher cIMT in young adulthood.

SUBMITTER: Menezes AMB

PROVIDER: S-EPMC5152614 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Adiposity during adolescence and carotid intima-media thickness in adulthood: Results from the 1993 Pelotas Birth Cohort.

Menezes Ana Maria Baptista AMB da Silva Cristiano Tschiedel Belem CTB Wehrmeister Fernando César FC Oliveira Paula Duarte PD Oliveira Isabel O IO Gonçalves Helen H Assunção Maria Cecilia F MCF de Castro Justo Fabiano F Barros Fernando C FC

Atherosclerosis 20161014

<h4>Background and aims</h4>Although several studies have examined the association between adiposity and cardiovascular risk markers, few have explored the issue prospectively in young populations. We sought to test whether higher levels of body mass index (BMI) and subscapular skinfold at different stages of adolescence were associated with carotid intima-media thickness (cIMT) in young adulthood.<h4>Methods</h4>In a prospective cohort, we assessed BMI and subscapular skinfold at 11, 15 and 18 ...[more]

PMID: 27816805

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Dataset Information

Adiposity during adolescence and carotid intima-media thickness in adulthood: Results from the 1993 Pelotas Birth Cohort.

Background and aims

Methods

Results

Conclusions

Publications

Adiposity during adolescence and carotid intima-media thickness in adulthood: Results from the 1993 Pelotas Birth Cohort.

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