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Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

ABSTRACT: Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.

SUBMITTER: Beavers KR

PROVIDER: S-EPMC5152671 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Beavers Kelsey R KR Werfel Thomas A TA Shen Tianwei T Kavanaugh Taylor E TE Kilchrist Kameron V KV Mares Jeremy W JW Fain Joshua S JS Wiese Carrie B CB Vickers Kasey C KC Weiss Sharon M SM Duvall Craig L CL

Advanced materials (Deerfield Beach, Fla.) 20160706 36

Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo. ...[more]

PMID: 27383910

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