Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.
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ABSTRACT:
SUBMITTER: Martin JR
PROVIDER: S-EPMC5152672 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.
Martin John R JR Nelson Christopher E CE Gupta Mukesh K MK Yu Fang F Sarett Samantha M SM Hocking Kyle M KM Pollins Alonda C AC Nanney Lillian B LB Davidson Jeffrey M JM Guelcher Scott A SA Duvall Craig L CL
Advanced healthcare materials 20160926 21
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds. ...[more]
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