Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.
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ABSTRACT:
SUBMITTER: Crowder SW
PROVIDER: S-EPMC5152909 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.
Crowder Spencer W SW Balikov Daniel A DA Boire Timothy C TC McCormack Devin D Lee Jung Bok JB Gupta Mukesh K MK Skala Melissa C MC Sung Hak-Joon HJ
Advanced healthcare materials 20160926 22
Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use. ...[more]
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