Connexin Remodeling Contributes to Atrial Fibrillation.
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ABSTRACT:
SUBMITTER: Jennings MM
PROVIDER: S-EPMC5153231 | biostudies-literature | 2013 Aug-Sep
REPOSITORIES: biostudies-literature
Publications
Connexin Remodeling Contributes to Atrial Fibrillation.
Jennings Michelle M MM Donahue J Kevin JK
Journal of atrial fibrillation 20130831 2
Atrial fibrillation significantly contributes to mortality and morbidity through increased risk of stroke, heart failure and myocardial infarction. Investigations of mechanisms responsible for the development and maintenance of atrial fibrillation have highlighted the importance of gap junctional remodeling. Connexins 40 and 43, the major atrial gap junctional proteins, undergo considerable alterations in expression and localization in atrial fibrillation, creating an environment conducive to su ...[more]
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