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Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

ABSTRACT: When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.

SUBMITTER: Bruyneel AA 

PROVIDER: S-EPMC5153828 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

Bruyneel Arne A N AA   Sehgal Apurv A   Malandraki-Miller Sophia S   Carr Carolyn C  

Journal of cardiovascular translational research 20160819 5-6

When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe vario  ...[more]

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