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Acetophenone Monomers from Acronychia trifoliolata.

ABSTRACT: Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH3OH/CH2Cl2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity.

SUBMITTER: Miyake K

PROVIDER: S-EPMC5154168 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Acetophenone Monomers from Acronychia trifoliolata.

Miyake Katsunori K Suzuki Airi A Morita Chihiro C Goto Masuo M Newman David J DJ O'Keefe Barry R BR Morris-Natschke Susan L SL Lee Kuo-Hsiung KH Nakagawa-Goto Kyoko K

Journal of natural products 20161024 11

Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH3OH/CH2Cl2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity ag ...[more]

PMID: 27797192

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Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata.

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2013-01-28 | GSE43779 | GEO

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