Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.
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ABSTRACT:
SUBMITTER: Green KD
PROVIDER: S-EPMC5154385 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.
Green Keith D KD Pricer Rachel E RE Stewart Megan N MN Garneau-Tsodikova Sylvie S
ACS infectious diseases 20150504 6
Antibiotic resistance is a growing problem worldwide. Of particular importance is the resistance of Mycobacterium tuberculosis (Mtb) to currently available antibiotics used in the treatment of infected patients. Up-regulation of an aminoglycoside (AG) acetyltransferase, the enhanced intracellular survival (Eis) protein of Mtb (Eis_Mtb), is responsible for resistance to the second-line injectable drug kanamycin A in a number of Mtb clinical isolates. This acetyltransferase is known to modify AGs, ...[more]
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