Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5154472 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yang Hongbing H Buisson Sandrine S Bossi Giovanna G Wallace Zoë Z Hancock Gemma G So Chun C Ashfield Rebecca R Vuidepot Annelise A Mahon Tara T Molloy Peter P Oates Joanne J Paston Samantha J SJ Aleksic Milos M Hassan Namir J NJ Jakobsen Bent K BK Dorrell Lucy L
Molecular therapy : the journal of the American Society of Gene Therapy 20160606 11
Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against viru ...[more]