Ontology highlight
ABSTRACT:
SUBMITTER: Smith JB
PROVIDER: S-EPMC5154474 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Smith Jenessa B JB Lanitis Evripidis E Dangaj Denarda D Buza Elizabeth E Poussin Mathilde M Stashwick Caitlin C Scholler Nathalie N Powell Daniel J DJ
Molecular therapy : the journal of the American Society of Gene Therapy 20160721 11
B7-H4 protein is frequently overexpressed in ovarian cancer. Here, we engineered T cells with novel B7-H4-specific chimeric antigen receptors (CARs) that recognized both human and murine B7-H4 to test the hypothesis that B7-H4 CAR T cell therapy can be applied safely in preclinical models. B7-H4 CAR T cells specifically secreted IFN-γ and lysed B7-H4(+) targets. In vivo, B7-H4 CAR T cells displayed antitumor reactivity against B7-H4(+) human ovarian tumor xenografts. Unexpectedly, B7-H4 CAR T ce ...[more]