Ontology highlight
ABSTRACT:
SUBMITTER: Mei W
PROVIDER: S-EPMC5154476 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Mei Wen W Xiang Guangda G Li Yixiang Y Li Huan H Xiang Lingwei L Lu Junyan J Xiang Lin L Dong Jing J Liu Min M
Molecular therapy : the journal of the American Society of Gene Therapy 20160809 11
Growth differentiation factor 11 (GDF11) reduces cardiac hypertrophy, improves cerebral vasculature and enhances neurogenesis in ageing mice. Higher growth differentiation factor 11/8 (GDF11/8) is associated with lower risk of cardiovascular events in humans. Here, we showed that adeno-associated viruses-GDF11 and recombinant GDF11 protein improve endothelial dysfunction, decrease endothelial apoptosis, and reduce inflammation, consequently decrease atherosclerotic plaques area in apolipoprotein ...[more]