Gestational maternal C--reactive protein and risk of bipolar disorder among young individuals in a Nationwide Birth Cohort.

ABSTRACT:

Objectives

C-reactive protein (CRP) is a well-established general marker of inflammation from both infectious and noninfectious exposures. Previous studies have shown that maternal CRP is associated with an increased risk of autism and schizophrenia. The aim of this study was to examine the association between early to mid-gestational serum CRP levels, prospectively assayed in maternal sera, and the risk of bipolar disorder (BPD).

Methods

This study is derived from the Finnish Prenatal Study of Bipolar Disorder (FIPS-B), based on a nested case-control study design. A total of 378 BPD cases and 378 controls, matched on date of birth and sex, with available maternal sera were identified from Finnish nationwide registers. Maternal CRP levels were assessed using a latex immunoas

SUBMITTER: Chudal R 

PROVIDER: S-EPMC5154883 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature