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Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.

ABSTRACT: Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ?-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and ?-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.

SUBMITTER: Kang H 

PROVIDER: S-EPMC5155334 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.

Kang Homan H   Gravier Julien J   Bao Kai K   Wada Hideyuki H   Lee Jeong Heon JH   Baek Yoonji Y   El Fakhri Georges G   Gioux Sylvain S   Rubin Brian P BP   Coll Jean-Luc JL   Choi Hak Soo HS  

Advanced materials (Deerfield Beach, Fla.) 20160714 37

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system. ...[more]

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