Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5155362 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wang Cong C Zhang Wenxue W Zhang Lin L Chen Xuan X Liu Fang F Zhang Jing J Guan Shanghui S Sun Yi Y Chen Pengxiang P Wang Ding D Un Nesa Effat E Cheng Yufeng Y Yousef George M GM
British journal of cancer 20161110 12
<h4>Background</h4>Our previous study found that dysregulated microRNA-146a-5p (miR-146a-5p) is involved in oesophageal squamous cell cancer (ESCC) proliferation. This article aimed to evaluate its detailed mechanisms in ESCC epithelial-mesenchymal transition (EMT) progression.<h4>Methods</h4>Invasion assay, qRT-PCR and western blotting were used to validate the roles of miR-146a-5p and Notch2 in EMT progression. miRNA target gene prediction databases and dual-luciferase reporter assay were used ...[more]