Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC5155541 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yu Miao M Liu Yu Y Li Jing J Natale Brianna N BN Cao Shuqin S Wang Dongliang D Amack Jeffrey D JD Hu Huaiyu H
Biology open 20161115 11
Mutations in the extracellular matrix protein eyes shut homolog (EYS) cause photoreceptor degeneration in patients with retinitis pigmentosa 25 (RP25). Functions of EYS remain poorly understood, due in part to the lack of an EYS gene in mouse. We investigated the localization of vertebrate EYS proteins and engineered loss-of-function alleles in zebrafish. Immunostaining indicated that EYS localized near the connecting cilium/transition zone in photoreceptors. EYS also strongly localized to the c ...[more]