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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.

ABSTRACT: Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

SUBMITTER: Jelenkovic A 

PROVIDER: S-EPMC5156525 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.

Jelenkovic Aline A   Hur Yoon-Mi YM   Sund Reijo R   Yokoyama Yoshie Y   Siribaddana Sisira H SH   Hotopf Matthew M   Sumathipala Athula A   Rijsdijk Fruhling F   Tan Qihua Q   Zhang Dongfeng D   Pang Zengchang Z   Aaltonen Sari S   Heikkilä Kauko K   Öncel Sevgi Y SY   Aliev Fazil F   Rebato Esther E   Tarnoki Adam D AD   Tarnoki David L DL   Christensen Kaare K   Skytthe Axel A   Kyvik Kirsten O KO   Silberg Judy L JL   Eaves Lindon J LJ   Maes Hermine H HH   Cutler Tessa L TL   Hopper John L JL   Ordoñana Juan R JR   Sánchez-Romera Juan F JF   Colodro-Conde Lucia L   Cozen Wendy W   Hwang Amie E AE   Mack Thomas M TM   Sung Joohon J   Song Yun-Mi YM   Yang Sarah S   Lee Kayoung K   Franz Carol E CE   Kremen William S WS   Lyons Michael J MJ   Busjahn Andreas A   Nelson Tracy L TL   Whitfield Keith E KE   Kandler Christian C   Jang Kerry L KL   Gatz Margaret M   Butler David A DA   Stazi Maria A MA   Fagnani Corrado C   D'Ippolito Cristina C   Duncan Glen E GE   Buchwald Dedra D   Derom Catherine A CA   Vlietinck Robert F RF   Loos Ruth Jf RJ   Martin Nicholas G NG   Medland Sarah E SE   Montgomery Grant W GW   Jeong Hoe-Uk HU   Swan Gary E GE   Krasnow Ruth R   Magnusson Patrik Ke PK   Pedersen Nancy L NL   Dahl-Aslan Anna K AK   McAdams Tom A TA   Eley Thalia C TC   Gregory Alice M AM   Tynelius Per P   Baker Laura A LA   Tuvblad Catherine C   Bayasgalan Gombojav G   Narandalai Danshiitsoodol D   Lichtenstein Paul P   Spector Timothy D TD   Mangino Massimo M   Lachance Genevieve G   Bartels Meike M   van Beijsterveldt Toos Cem TC   Willemsen Gonneke G   Burt S Alexandra SA   Klump Kelly L KL   Harris Jennifer R JR   Brandt Ingunn I   Nilsen Thomas Sevenius TS   Krueger Robert F RF   McGue Matt M   Pahlen Shandell S   Corley Robin P RP   Hjelmborg Jacob V B JV   Goldberg Jack H JH   Iwatani Yoshinori Y   Watanabe Mikio M   Honda Chika C   Inui Fujio F   Rasmussen Finn F   Huibregtse Brooke M BM   Boomsma Dorret I DI   Sørensen Thorkild I A TI   Kaprio Jaakko J   Silventoinen Karri K  

eLife 20161214

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing  ...[more]