Toward the atomic structure of the nuclear pore complex: when top down meets bottom up.
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ABSTRACT:
SUBMITTER: Hoelz A
PROVIDER: S-EPMC5156573 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up.
Hoelz André A Glavy Joseph S JS Beck Martin M
Nature structural & molecular biology 20160606 7
Elucidating the structure of the nuclear pore complex (NPC) is a prerequisite for understanding the molecular mechanism of nucleocytoplasmic transport. However, owing to its sheer size and flexibility, the NPC is unapproachable by classical structure determination techniques and requires a joint effort of complementary methods. Whereas bottom-up approaches rely on biochemical interaction studies and crystal-structure determination of NPC components, top-down approaches attempt to determine the s ...[more]
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