Ontology highlight
ABSTRACT:
SUBMITTER: Ramwadhdoebe TH
PROVIDER: S-EPMC5157721 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ramwadhdoebe Tamara H TH Hähnlein Janine J Maijer Karen I KI van Boven Leonard J LJ Gerlag Danielle M DM Tak Paul P PP van Baarsen Lisa G M LG
European journal of immunology 20161012 12
The balance between proinflammatory and regulatory CD4<sup>+</sup> T cells is tightly controlled in lymphoid organs. In autoimmune diseases this balance is altered in the periphery and target tissue of patients. However, not much is known about the balance initiated in lymphoid organs during the development of disease. Since systemic autoimmunity is present years before the clinical manifestations of rheumatoid arthritis (RA), it is possible to study the immunoregulatory balance during the earli ...[more]