Ontology highlight
ABSTRACT:
SUBMITTER: Landau ID
PROVIDER: S-EPMC5158120 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Landau Itamar D ID Egger Robert R Dercksen Vincent J VJ Oberlaender Marcel M Sompolinsky Haim H
Neuron 20161117 5
Models of cortical dynamics often assume a homogeneous connectivity structure. However, we show that heterogeneous input connectivity can prevent the dynamic balance between excitation and inhibition, a hallmark of cortical dynamics, and yield unrealistically sparse and temporally regular firing. Anatomically based estimates of the connectivity of layer 4 (L4) rat barrel cortex and numerical simulations of this circuit indicate that the local network possesses substantial heterogeneity in input ...[more]