Present Yourself! By MHC Class I and MHC Class II Molecules.
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ABSTRACT:
SUBMITTER: Rock KL
PROVIDER: S-EPMC5159193 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Present Yourself! By MHC Class I and MHC Class II Molecules.
Rock Kenneth L KL Reits Eric E Neefjes Jacques J
Trends in immunology 20160907 11
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunot ...[more]
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