Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
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ABSTRACT:
SUBMITTER: Devlin AS
PROVIDER: S-EPMC5159218 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
Devlin A Sloan AS Marcobal Angela A Dodd Dylan D Nayfach Stephen S Plummer Natalie N Meyer Tim T Pollard Katherine S KS Sonnenburg Justin L JL Fischbach Michael A MA
Cell host & microbe 20161201 6
Renal disease is growing in prevalence and has striking co-morbidities with metabolic and cardiovascular disease. Indoxyl sulfate (IS) is a toxin that accumulates in plasma when kidney function declines and contributes to the progression of chronic kidney disease. IS derives exclusively from the gut microbiota. Bacterial tryptophanases convert tryptophan to indole, which is absorbed and modified by the host to produce IS. Here, we identify a widely distributed family of tryptophanases in the gut ...[more]
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