Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez-Arango P
PROVIDER: S-EPMC5159530 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Vazquez-Arango Pilar P Vowles Jane J Browne Cathy C Hartfield Elizabeth E Fernandes Hugo J R HJ Mandefro Berhan B Sareen Dhruv D James William W Wade-Martins Richard R Cowley Sally A SA Murphy Shona S O'Reilly Dawn D
Nucleic acids research 20160817 22
The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processing events. We recently demonstrated that a new class of human U1-like snRNAs, the variant (v)U1 snRNAs (vU1s), also participate in pre-mRNA processing events. In this study, we show that several human vU1 genes are specifically upregulated in stem cells and participate in the regulation of cell fate decisions. Significantly, ectopic expression of vU1 ...[more]