Ontology highlight
ABSTRACT:
SUBMITTER: Christmann M
PROVIDER: S-EPMC5159553 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Christmann Markus M Boisseau Catherine C Kitzinger Rebekka R Berac Christian C Allmann Sebastian S Sommer Tina T Aasland Dorthe D Kaina Bernd B Tomicic Maja T MT
Nucleic acids research 20160930 22
A coordinated and faithful DNA damage response is of central importance for maintaining genomic integrity and survival. Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH ...[more]