Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC5159653 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Yang Fan F Hsu Peter P Lee Susan D SD Yang Wen W Hoskinson Derick D Xu Weihao W Moore Claire C Varani Gabriele G
RNA (New York, N.Y.) 20161025 1
3'-End processing of pre-mRNAs prior to packaging and export to the cytoplasm of the mature transcript is a highly regulated process executed by several tens of protein factors that recognize poorly conserved RNA signals. Among them is Pcf11, a highly conserved, multidomain protein that links transcriptional elongation, 3'-end processing, and transcription termination. Here we report the structure and biochemical function of Pcf11's C-terminal domain, which is conserved from yeast to humans. We ...[more]