Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants.
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ABSTRACT:
SUBMITTER: Yilmazer YB
PROVIDER: S-EPMC5159827 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants.
Yilmazer Yasemin B YB Koganezawa Masayuki M Sato Kosei K Xu Jinhua J Yamamoto Daisuke D
Nature communications 20161213
Drosophila platonic (plt) males court females, but fail to copulate. Here we show that plt is an allele of scribbler (sbb), a BMP signalling component. sbb knockdown in larvae leads to the loss of approximately eight serotonergic neurons, which express the sex-determinant protein Doublesex (Dsx). Genetic deprivation of serotonin (5-HT) from dsx-expressing neurons results in copulation defects. Thus, sbb<sup>+</sup> is developmentally required for the survival of a specific subset of dsx-expressi ...[more]
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