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Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

ABSTRACT: The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.

SUBMITTER: Emile JF

PROVIDER: S-EPMC5161007 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

Emile Jean-François JF Abla Oussama O Fraitag Sylvie S Horne Annacarin A Haroche Julien J Donadieu Jean J Requena-Caballero Luis L Jordan Michael B MB Abdel-Wahab Omar O Allen Carl E CE Charlotte Frédéric F Diamond Eli L EL Egeler R Maarten RM Fischer Alain A Herrera Juana Gil JG Henter Jan-Inge JI Janku Filip F Merad Miriam M Picarsic Jennifer J Rodriguez-Galindo Carlos C Rollins Barret J BJ Tazi Abdellatif A Vassallo Robert R Weiss Lawrence M LM

Blood 20160310 22

The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. ...[more]

PMID: 26966089

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Dataset Information

Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

Publications

Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

Similar Datasets

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