Ontology highlight
ABSTRACT:
SUBMITTER: Hisamoto N
PROVIDER: S-EPMC5161311 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hisamoto Naoki N Nagamori Yuki Y Shimizu Tatsuhiro T Pastuhov Strahil I SI Matsumoto Kunihiro K
PLoS genetics 20161216 12
The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. However, the signaling pathways that orchestrate axon regeneration are not well understood. In Caenorhabditis elegans, initiation of axon regeneration is positively regulated by SVH-2 Met-like growth factor receptor tyrosine kinase (RTK) signaling through the JNK MAPK pathway. Here we show that SVH-4/DDR-2, an RTK containing a discoidin domain that is activated by collagen, ...[more]