Dataset Information

Health-Related Quality of Life Impairment and Indirect Cost of Crohn's Disease: A Self-Report Study in Poland.

ABSTRACT:

Background and aims

Evidence on indirect cost of Crohn's disease (CD) is available but typically provides information on the loss of productivity at paid work of patients. In the present study, the quality of life and indirect costs of CD patients were assessed (overall and by disease severity).

Methods

A self-report questionnaire-based study among adult Polish patients with CD was performed. We collected data on patients' characteristics, quality of life, loss of productivity, consumption of medical resources, and out-of-pocket expenses. The disease severity was determined using the patient's version of the Harvey-Bradshaw index. Productivity costs were assessed from the social perspective, using a human capital approach. The cost of absenteeism, presenteeism and permanent work disability was valuated using the gross domestic product per worker. The patients' productivity loss at unpaid work was measured by time inputs of others to assist patients. The productivity loss among informal caregivers and patients' productivity loss at unpaid work were valuated with the average wage in Poland. The results were adjusted for confounders.

Results

The responses from 200 patients (47% in remission) were analysed. The mean utility index was 0.839 (SD 0.171). The total indirect cost was estimated at €462.47 per patient per month (24.0%, absenteeism; 35.0%, work disability; 30.4%, presenteeism; 0.4%, productivity loss at unpaid work; and 10.4%, informal care). A significant correlation of the quality of life and productivity losses with disease severity was observed. Compared with active disease, the remission subgroup had a higher utility index by 16% (p<0.001) and lower indirect costs by 71% (p = 0.003) for absenteeism, 41% (p = 0.030) for presenteeism, 76% (p<0.001) for productivity loss at unpaid work, and 75% (p<0.001) for informal care.

Conclusions

Our study revealed the social burden of CD and high dependency of indirect costs and quality of life on the severity of CD in Poland.

SUBMITTER: Holko P

PROVIDER: S-EPMC5161376 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Health-Related Quality of Life Impairment and Indirect Cost of Crohn's Disease: A Self-Report Study in Poland.

Holko Przemysław P Kawalec Paweł P Mossakowska Małgorzata M Pilc Andrzej A

PloS one 20161216 12

<h4>Background and aims</h4>Evidence on indirect cost of Crohn's disease (CD) is available but typically provides information on the loss of productivity at paid work of patients. In the present study, the quality of life and indirect costs of CD patients were assessed (overall and by disease severity).<h4>Methods</h4>A self-report questionnaire-based study among adult Polish patients with CD was performed. We collected data on patients' characteristics, quality of life, loss of productivity, co ...[more]

PMID: 27992531

Similar Datasets

Project description:IntroductionThe new, five-level EQ-5D generic questionnaire (EQ-5D-5L) has never been used among diabetes patients in Poland.ObjectivesTo develop health-related quality of life (HRQoL) norms for patients with self-reported diabetes, based on a large representative sample of the general Polish population, using the EQ-5D-5L.Materials and methodsMembers of the general public, selected via multistage stratified sampling, filled in the EQ-5D-5L questionnaire and answered a question about the presence of diabetes. We estimated three types of EQ-5D-5L outcomes: limitations within domains, EQ VAS and EQ-5D-5L index. Multiple linear regression was used to examine the relationship between sociodemographic characteristics and HRQoL, both in patients with diabetes and the general population sample.ResultsAmong 2,973 respondents having complete EQ-5D-5L data, 255 subjects (8.6%) self-reported diabetes. Treatment with insulin, other drugs, combination therapy or lack of drug treatment was declared by 22.0%, 48.6%, 5.1% and 24.3% of patients, respectively. Respondents with diabetes had a lower EQ VAS score (18.5 points difference on a 100-points scale) and a lower EQ-5D-5L index score (0.135 difference; scale range: 1.59). The multivariate analysis showed that the factors independently improving the HRQoL in the general population were secondary or higher education, and factors reducing HRQoL were female sex, belonging to an older age group, being treated because of diabetes with insulin, other drugs or combination treatment. Respondents diagnosed with diabetes but not treated with drugs showed a decrease in EQ VAS scores, but not in the EQ-5D-5L index.ConclusionsDiabetes leads to HRQoL deterioration in all age groups when compared to matched general population respondents without diabetes. The most significant HRQoL reduction experience older patients with a basic level of education. Obtained EQ-5D-5L normative data may be used in the clinical care of patients with diabetes and health technology assessment of new anti-diabetic drugs.

Project description:BackgroundMental and physical health problems among the farming community are well documented but there is limited evidence regarding the overall health status of this population. This paper offers a unique insight into this issue through presenting the findings from a survey instrument, the EQ-5D-3L, which provides a standardised measure of health-related quality of life (HRQOL).MethodsWe conducted the largest ever survey (n = 15,296) of people living and working in agriculture in England and Wales to gather baseline data on health and wellbeing within this community. The survey included an assessment of HRQOL through the use of the EQ-5D-3L self-report questionnaire. A variety of statistical approaches were used to test for significant associations between HRQOL and sub-group characteristics, including the Chi-square test for independence, the Kruskal-Wallis test, and Mann-Whitney U-test. Binary logistic regression models were also created to assess the influence of a set of respondent characteristics on the likelihood of respondents reporting health problems in the EQ-5D-3L.Results24% of respondents reported problems with mobility; 4% reported problems with self-care; 21% reported problems with performing their usual activities; 52% reported problems with pain/discomfort; and 31% reported problems with anxiety/depression. The mean EQ-5D index value was 0.811 (median (Md) 0.796, interquartile range (IQR) 0.275). The mean self-rated health score (EQ-VAS) was 77.6 (SD 16.1) (Md 80.0, IQR 20). In general, holding other respondent characteristics equal, women reported fewer problems with mobility, self-care, performing usual activities and pain/discomfort than men, but more problems with anxiety/depression. HRQOL in the working-aged appears to be poorer among the survey population than the wider UK population.ConclusionsResults reveal concerning levels of physical and mental health problems, especially pain/discomfort and anxiety/depression, which appear to be more prevalent within our sample than within the wider UK population. There were important gender and age-related differences in both mental and physical health. Combatting these problems through targeted support is essential for the wellbeing of the farming community and the future sustainability of UK food production.

Dataset Information

Health-Related Quality of Life Impairment and Indirect Cost of Crohn's Disease: A Self-Report Study in Poland.

Background and aims

Methods

Results

Conclusions

Publications

Health-Related Quality of Life Impairment and Indirect Cost of Crohn's Disease: A Self-Report Study in Poland.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets