Ontology highlight
ABSTRACT:
SUBMITTER: Pacheco-Leyva I
PROVIDER: S-EPMC5161512 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pacheco-Leyva Ivette I Matias Ana Catarina AC Oliveira Daniel V DV Santos João M A JM Nascimento Rita R Guerreiro Eduarda E Michell Anna C AC van De Vrugt Annebel M AM Machado-Oliveira Gisela G Ferreira Guilherme G Domian Ibrahim I Bragança José J
Stem cell reports 20161103 6
The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC). The overexpression of CITED2 in undifferentiated ESC was sufficient to promote cardiac cell emergence upon differentiation. Conversely, the depletion of Cited2 at the onset of differentiation resulted in a decline of ESC ability to generate cardiac cells. Moreover, loss of Cited2 expression impairs the e ...[more]