Ontology highlight
ABSTRACT:
SUBMITTER: McNamara RK
PROVIDER: S-EPMC5161539 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
McNamara Robert K RK Moser Ann B AB Jones Richard I RI Jandacek Ronald R Patino L Rodrigo LR Strawn Jeffrey R JR Strakowski Stephen M SM DelBello Melissa P MP
Psychiatry research 20161025
Bipolar I disorder is associated with deficits in the long-chain omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3). The final biosynthesis of DHA is mediated by peroxisomes, and some heritable peroxisomal disorders are associated with DHA deficits and progressive psychopathology. The present cross-sectional study investigated whether medication-free asymptomatic and symptomatic youth with familial risk for bipolar I disorder exhibit impaired peroxisomal function using a comprehensive diagno ...[more]