Ontology highlight
ABSTRACT:
SUBMITTER: Gulick AM
PROVIDER: S-EPMC5161630 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Current opinion in chemical biology 20160925
Nonribosomal peptide synthetases (NRPSs) catalyze the assembly line biosynthesis of peptide natural products that play important roles in microbial signaling and communication. These multidomain enzymes use an integrated carrier protein that delivers the growing peptide to the catalytic domains, requiring coordinated conformational changes that allow the proper sequence of synthetic steps. Recent structural studies of NRPSs have described important conformational states and illustrate the critic ...[more]