Ontology highlight
ABSTRACT:
SUBMITTER: Dennis MY
PROVIDER: S-EPMC5161654 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Dennis Megan Y MY Eichler Evan E EE
Current opinion in genetics & development 20160830
Duplications are the primary force by which new gene functions arise and provide a substrate for large-scale structural variation. Analysis of thousands of genomes shows that humans and great apes have more genetic differences in content and structure over recent segmental duplications than any other euchromatic region. Novel human-specific duplicated genes, ARHGAP11B and SRGAP2C, have recently been described with a potential role in neocortical expansion and increased neuronal spine density. La ...[more]