Structural insight into the role of the Ton complex in energy transduction.
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ABSTRACT:
SUBMITTER: Celia H
PROVIDER: S-EPMC5161667 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Structural insight into the role of the Ton complex in energy transduction.
Celia Hervé H Noinaj Nicholas N Zakharov Stanislav D SD Bordignon Enrica E Botos Istvan I Santamaria Monica M Barnard Travis J TJ Cramer William A WA Lloubes Roland R Buchanan Susan K SK
Nature 20160921 7623
In Gram-negative bacteria, outer membrane transporters import nutrients by coupling to an inner membrane protein complex called the Ton complex. The Ton complex consists of TonB, ExbB, and ExbD, and uses the proton motive force at the inner membrane to transduce energy to the outer membrane via TonB. Here, we structurally characterize the Ton complex from Escherichia coli using X-ray crystallography, electron microscopy, double electron-electron resonance (DEER) spectroscopy, and crosslinking. O ...[more]
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