Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC5161668 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Yang Feng F Chen Tai-Yen TY Krzemiński Łukasz Ł Santiago Ace George AG Jung Won W Chen Peng P
Molecular microbiology 20160930 6
In bacteria, trigger factor (TF) is the molecular chaperone that interacts with the ribosome to assist the folding of nascent polypeptides. Studies in vitro have provided insights into the function and mechanism of TF. Much is to be elucidated, however, about how TF functions in vivo. Here, we use single-molecule tracking, in combination with genetic manipulations, to study the dynamics and function of TF in living E. coli cells. We find that TF, besides interacting with the 70S ribosome, may al ...[more]