Higher circulating adiponectin levels are associated with increased risk of atrial fibrillation in older adults.

ABSTRACT:

Background

Adiponectin has cardioprotective properties, suggesting that lower levels seen in obesity and diabetes could heighten risk of atrial fibrillation (AF). Among older adults, however, higher adiponectin has been linked to greater incidence of adverse outcomes associated with AF, although recent reports have shown this association to be U-shaped. We postulated that higher adiponectin would be linked to increased risk for AF in older adults in a U-shaped manner.

Methods

We examined the associations of total and high-molecular-weight (HMW) adiponectin with incident AF among individuals free of prevalent cardiovascular disease (CVD) participating in a population-based cohort study of older adults (n=3190; age=74±5 years).

Results

During median follow-up of 11.4 ye

SUBMITTER: Macheret F 

PROVIDER: S-EPMC5161822 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature