Ontology highlight
ABSTRACT:
SUBMITTER: Arsenault PR
PROVIDER: S-EPMC5163474 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Arsenault Patrick R PR Song Daisheng D Bergkamp Marian M Ravaschiere Andrew M AM Navalsky Bradleigh E BE Lieberman Paul M PM Lee Frank S FS
Chembiochem : a European journal of chemical biology 20161111 24
The prolyl hydroxylase domain (PHD) protein:hypoxia inducible factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating HIF target genes such as erythropoietin (EPO), which controls red cell mass and hematocrit. PHD2 is distinctive among the three PHDs in that it contains an N-terminal MYND-type zinc finger. We have p ...[more]