Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.
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ABSTRACT:
SUBMITTER: Armbruester V
PROVIDER: S-EPMC516385 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Publications
Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.
Armbruester Vivienne V Sauter Marlies M Roemer Klaus K Best Barbara B Hahn Steffen S Nty Achille A Schmid Andreas A Philipp Stephan S Mueller Anja A Mueller-Lantzsch Nikolaus N
Journal of virology 20041001 19
We have recently identified Np9 as a novel nuclear protein produced by the human endogenous retrovirus K and were able to document the exclusive presence of np9 transcript in tumors and transformed cells. With the aim of studying whether Np9 has a role in tumorigenesis, a systematic search for interacting proteins was performed. Here, we identify the RING-type E3 ubiquitin ligase LNX (ligand of Numb protein X) as an Np9-interacting partner. We furthermore show that the interaction involves N- an ...[more]
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