Ontology highlight
ABSTRACT:
SUBMITTER: Ross JL
PROVIDER: S-EPMC516494 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Ross Jennifer L JL Santangelo Christian D CD Makrides Victoria V Fygenson D Kuchnir DK
Proceedings of the National Academy of Sciences of the United States of America 20040823 35
Taxol and tau are two ligands that stabilize the microtubule (MT) lattice. Taxol is an anti-mitotic drug that binds beta tubulin in the MT interior. Tau is a MT-associated protein that binds both alpha and beta tubulin on the MT exterior. Both Taxol and tau reduce MT dynamics and promote tubulin polymerization. Tau alone also acts to bundle, stiffen, and space MTs. A structural study recently suggested that Taxol and tau may interact by binding to the same site. Using fluorescence recovery after ...[more]