Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC516510 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Chen Zhiping Z Keaney John F JF Schulz Eberhard E Levison Bruce B Shan Lian L Sakuma Masashi M Zhang Xiaobin X Shi Can C Hazen Stanley L SL Simon Daniel I DI
Proceedings of the National Academy of Sciences of the United States of America 20040817 35
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced, in part, from NADPH oxidase in response to host invasion and tissue injury. Defects in NADPH oxidase impair host defense; however, the role of ROS and RNS in the response to tissue injury is not known. We addressed this issue by subjecting leukocyte oxidase (Nox2)-deficient (Nox2-/-) mice to arterial injury. Femoral artery injury was associated with increased Nox2 expression, ROS/RNS production, and oxidative protein ...[more]